Journal article
Spectroscopic study of L-DOPA and dopamine binding on novel gold nanoparticles towards more efficient drug-delivery system for Parkinson's disease
N Kalčec, N Peranić, R Barbir, CR Hall, TA Smith, MA Sani, R Frkanec, F Separovic, I Vinković Vrček
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy | Published : 2022
Abstract
Nano-drug delivery systems may potentially overcome current challenges in the treatment of Parkinson's disease (PD) by enabling targeted delivery and more efficient blood–brain penetration ability. This study investigates novel gold nanoparticles (AuNPs) to be used as delivery systems for L-DOPA and dopamine by considering their binding capabilities in the presence and absence of a model protein, bovine serum albumin (BSA). Four different AuNPs were prepared by surface functionalization with polyethylene glycol (PEG), 1-adamantylamine (Ad), 1-adamantylglycine (AdGly), and peptidoglycan monomer (PGM). Fluorescence and UV–Vis measurements demonstrated the strongest binding affinity and L-DOPA/..
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Grants
Awarded by European Commission
Funding Acknowledgements
This study was financially supported by the "Research Cooperability"Program of the Croatian Science Foundation funded by the European Union from the European Social Fund under the Operational Programme Efficient Human Resources 2014 ~ 2020 (grant HRZZ-PZS-2019-02-4323). We gratefully acknowledge support from the Australian Research Council Centre of Excellence in Exciton Science (CE170100026) and the Croatian Science Foundation (grant HRZZ-IP-2018-01-6910).